Pegylated Solid dispersion of diclofenac was prepared to achieve improved bioavailability. Currently only 8% of new drug candidates have both high solubility and permeability. More than 60% of potential drug products suffer from poor water solubility. This frequently results in potentially important products not reaching the market or not achieving their full potential. Experience with solid dispersions over the last 20-30 years indicates that this is a very fruitful approach to improving the release rate and oral bioavailability of poorly water soluble drugs. So this article highlights technology various approaches for the preparation of solid dispersion, technology involved, detail description of poorly water soluble drugs & carriers. The purpose of this study is to fabricate the polyethylene glycol matrix tablet by mold technique. Diclofenac and hydroxyl propyl methyl cellulose were used as model drug and polymer, respectively, in PEG matrix system. Scanning electron microscope photomicrograph indicated the drug diffusion outward through the porous network of this developed matrix tablet into the dissolution fluid. Both the enhancement of drug dissolution and the prolongation of the drug release could be achieved for aqueous insoluble drug such as, Diclofenac by using polyethylene glycol-hydroxy propyl methylcellulose matrix system prepared with melting and mold technique.
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